2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W699983
    Imidazole-15N2 74362-46-2 98%
    Imidazole-15N2 (Glyoxaline-15N2) is 15N labeled Imidazole. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease.
    Imidazole-15N2
  • HY-W700174
    3-(4-Chlorophenyl)-4-hydroxybutyric acid sodium 1346603-21-1 98%
    3-(4-Chlorophenyl)-4-hydroxybutyric acid sodium is an inactive metabolite of the GABAB receptor agonist Baclofen (HY-B0007).
    3-(4-Chlorophenyl)-4-hydroxybutyric acid sodium
  • HY-W700639
    Tolafentrine 139308-65-9 98%
    Tolafentrine, a dual-selective phosphodiesterase 3/4 (PDE3/4) inhibitor, has been shown to have significant acute and chronic effects in a unilateral diacetamide-induced rat pulmonary hypertension model. Experiments show that long-term administration can significantly alleviate all unilateral bisacetamide-induced hemodynamic and gas exchange abnormalities, reduce right ventricular hypertrophy, and normalize pulmonary vascular remodeling changes.
    Tolafentrine
  • HY-W700834
    Harman-d3 1216708-84-7 98%
    Harman-d3 is deuterium labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC50=7 μM), with IC50 values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC50 values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC50=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF).
    Harman-d3
  • HY-W701743
    3,4-Dihydroxyamphetamine hydrochloride 828-06-8 98%
    3,4-Dihydroxyamphetamine (α-Methyldopamine) (hydrochloride) is a secondary metabolite of 3,4-Methylenedioxymethamphetamine (MDMA). 3, 4-dihydroxyamphetamine (hydrochloride) is cytotoxic to rat hepatocytes. 3, 4-dihydroxyamphetamine (hydrochloride) is also used in the study of high blood pressure.
    3,4-Dihydroxyamphetamine hydrochloride
  • HY-W705106
    (-)-Coclaurine hydrochloride 3422-42-2 98%
    (-)-Coclaurine hydrochloride (compound I) is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum. (-)-Coclaurine hydrochloride is a nicotinic acetylcholine receptor (nAChRs) antagonist.
    (-)-Coclaurine hydrochloride
  • HY-W709760
    7-hydroxychlorpromazine 2095-62-7 98%
    7-Hydroxychlorpromazine is an active metabolite of Chlorpromazine (HY-12708). 7-Hydroxychlorpromazine reverses Amphetamine-induced depression of regional compact dopaminergic neurons.
    7-hydroxychlorpromazine
  • HY-W714117
    GBR-12879 methanesulfonate 77862-93-2 98%
    GBR-12879 methanesulfonate acts as a dopamine reuptake inhibitor.
    GBR-12879 methanesulfonate
  • HY-W714513
    VU0469650 hydrochloride 98%
    VU0469650 hydrochloride is a brain-penetrant negative allosteric modulator of metabotropic glutamate receptor 1 (mGluR1). VU0469650 hydrochloride inhibits glutamate-induced calcium flux in cells expressing human mGluR1 (IC50= 99 nM). VU0469650 hydrochloride is promising for research of central nervous system diseases such as anxiety, addiction, and epilepsy.
    VU0469650 hydrochloride
  • HY-W721480
    HC-067047 hydrochloride 1481646-76-7 98%
    HC-067047 hydrochloride is a potent and selective TRPV4 antagonist and reversibly inhibits currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 48 nM, 133 nM, and 17 nM, respectively.
    HC-067047 hydrochloride
  • HY-W725496
    D-Fructose 6-phosphate dipotassium 103213-47-4 98%
    D-Fructose 6-phosphate dipotassium is an endogenous metabolite in saliva that affects cell growth and autophagy; it can be hydrolyzed by Fructose-1,6-bisphosphatase (FBPase). D-Fructose 6-phosphate dipotassium can be converted into D-glucose 6-phosphate (HY-112537) by the action of phosphoglucose isomerase. D-Fructose 6-phosphate dipotassium is a sugar intermediate in the glycolysis pathway and the pentose phosphate pathway. D-Fructose 6-phosphate dipotassium can be used to study Lewy body dementia.
    D-Fructose 6-phosphate dipotassium
  • HY-W727031
    2-Methylamino-1-phenylbutane hydrochloride 84952-63-6 98%
    2-Methylamino-1-phenylbutane hydrochloride is a metabolite of stimulant agents in blood.
    2-Methylamino-1-phenylbutane hydrochloride
  • HY-W728451
    URB694 904672-77-1 98%
    URB694 is a carbamate FAAH inhibitor that irreversibly carbamoylate the nucleophile catalytic serine in FAAH active site. URB694 exhibits antidepressant-like activity and cardioprotective effects. URB694 can be used to prepare 11C-Carbonyl-URB694 for in vivo positron emission tomography (PET) imaging studies of the brain FAAH.
    URB694
  • HY-W741575
    Iloperidone carboxylic acid 475110-48-6 98%
    Iloperidone carboxylic acid (P95-12113) is the metabolite of Iloperidone (HY-17410). Iloperidone carboxylic acid exhibits good affinity for 5-HT2A receptor with pKi of 8.15, and moderate affinity for adrenergic receptor α1/α2B/α2C.
    Iloperidone carboxylic acid
  • HY-W742532
    ETH-LAD 65527-62-0 98%
    ETH-LAD (N-Ethyl-nor-LSD) is an activator for 5-HT2A receptor with Ki of 5.1 nM. ETH-LAD exhibits affinity for dopamine receptor D1 and dopamine receptor D2 with Ki of 22.1 nM and 4.4 nM. ETH-LAD acts as psychoactive substance in rat model.
    ETH-LAD
  • HY-W743888
    AL-LAD 65527-61-9 98%
    AL-LAD (6-Allyl-6-nor-LSD) is an activator for 5-HT2A receptor with Ki of 3.4-8.1 nM. AL-LAD exhibits affinity for dopamine receptor D1 and dopamine receptor D2 with absolute affinitiesK0.5 of 189 nM and 12.3 nM. AL-LAD acts as psychoactive substance in mouse model.
    AL-LAD
  • HY-W746031
    WAY-181187 hydrochloride 554403-08-6 98%
    WAY-181187 (SAX-187) hydrochloride is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM. WAY-181187 hydrochloride mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist.
    WAY-181187 hydrochloride
  • HY-W747594
    SDZ PCO 400 121055-10-5 98%
    SDZ PCO 400 is a potassium channel modulator that relaxes airway smooth muscle and reverses airway obstruction caused by intravenous bronchospasmodics.
    SDZ PCO 400
  • HY-W749797
    Nitrazolam 28910-99-8 98%
    Nitrazolam is a benzodiazepine compound, that may exhibit CNS depressant properties as traditional benzodiazepines, including sedation, hypnosis, anxiolysis, and anticonvulsant effects, by acting on GABA receptors.
    Nitrazolam
  • HY-W749852
    Xanthine (sodium), 98% 1196-43-6 98%
    Xanthine sodium, 98%, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine sodium, 98% also acts as an intermediate product on the pathway of purine degradation.
    Xanthine (sodium), 98%
Cat. No. Product Name / Synonyms Application Reactivity